The cover of the boundary-pushing French satirical magazine is obviously referencing the police killing of George Floyd, a Black American man.
"If you could care less about it, why did you go out of your way to make an eight-minute video about the situation?" one Twitter user hit back at Donald Trump's son.
Pierce called the interview "insignificant" amid the pandemic, but said the duchess "would always have a friend in me."
The Duke and Duchess of Sussex made astonishing revelations during their two-hour special with Oprah Winfrey on CBS.
Buckingham Palace is under pressure to address stunning allegations of racism from the Duke and Duchess of Sussex.
The couple spoke honestly about mental health and so did the Australian actor.
Misan Harriman posted the photo after the couple announced they're expecting a baby girl in their sit-down interview with Oprah.
The couple told Oprah Winfrey they moved to America in “large part” because of racism and that Harry's family has not apologised.
The Duke and Duchess of Sussex previously revealed certain members of the royal family had "concerns and conversations" about their son's skin color before he was born.
The couple did not hold back during their two-hour chat with the veteran talk show host.