McGowan alleged that Weinstein engaged in racketeering to silence her and derail her career before she accused him of rape.
The actor slammed Winfrey for her relationship with the disgraced film executive and for "supporting a sick power structure for personal gain."
The "Charmed" actor accused "Hollywood cult leaders" of enabling his alleged abuse.
The actor alleges that when she was a teen, the director showed her a “soft-core porn movie” at his apartment and exposed himself to her.
"I want to say, I have tried, and I will keep trying," Portman said of McGowan’s claims that her support of female directors is disingenuous.
Portman’s cape, which was embroidered with the names of snubbed female directors, inspired McGowan to write a lengthy post “out of disgust.”
Several of his accusers, such as actors Rosanna Arquette and Rose McGowan, also criticized Weinstein’s defenders and enablers in Hollywood.
The actress tweeted on Monday to the disgraced movie mogul, "I didn’t forget you, Harvey. My body didn’t forget you. I wish it could."
"It all got eviscerated because of what happened," the accused rapist and former movie mogul complained in a new interview.
The actress filed a lawsuit accusing Harvey Weinstein and his former attorneys of conspiring to silence and discredit his alleged victims of sexual assault.