Rayne collapsed and died at her San Fernando Valley home, Assistant Chief Coroner Ed Winter told the Daily News. She was 31.
"It was reported as a possible accident, a possible overdose," Winter said, adding that toxicology results were not yet available.
Rayne's name emerged in December when she came forward to claim that Deen escalated an anal-sex scene by punching her and thrusting inside her to the point where she had to go to the hospital. Deen said he did nothing wrong.
Lexi Love, a former porn actress and friend, told The Huffington Post on Monday: "I'm in shock and very sad. I used to hang out with her quite a bit outside the industry. We'd see each other a couple of times a year and go to Broadway shows."
Love added that Rayne had already "been through so much" and was "sick with cancer" a few years ago. She declined comment on Rayne's claims against Deen.
She expressed her sentiments on social media.