It was the duo's seventh year hosting the network's New Year's Eve special, continuing a tradition that has seen Griffin strip down to her bra, attempt to simulate sex acts and drop the f-bomb in years past.
On Tuesday, Cooper made a fruitless attempt to control Griffin with a large poster listing the ground rules: "No Swearing, No Stripping, No Touching, No Simulations." She responded by signing Miley Cyrus' name.
Later, Cooper appeared baffled when Griffin snapped handcuffs on him and declared that she didn't have a key. "Why are you attempting to handcuff yourself to me?" he asked, laughing.
"I have been planning this for weeks," a triumphant Griffin said. "Only three people in the world knew I was going to do this."
"This is truly my worst nightmare," Cooper said. "I will gnaw off my hand."
Viewers did not get to see Cooper free himself before midnight, but the CNN host later tweeted: