Biden gets choked up when talking about the struggles of American families and the trials he himself went through when his wife and young daughter were killed in a car accident.
"The notion that somehow because I am a man I don't know how to raise two kids on my own," he says, "I know what its like to raise a child where you are not sure he's going to make it."
At one point he had to hold back tears, take a breath and compose himself.
On the CNN dials of undecided voters in Ohio, both men and women rated the moment as high as possible.
Advertisement
Watch: