McCaskill and many Democrats have felt the wrath of voters during the fierce partisan clash over the party's effort to overhaul the health insurance system. At a protest at her St. Louis office on Dec. 23, some in the crowd carried unflattering depictions of McCaskill with the words, "Obama's Joker." She doesn't stand for re-election until 2012.
"It's OK if I don't get re-elected," she said in an interview. "I've just kind of decided that, hey, I'm just going to do this, and Missouri's hard, so there's a chance, you know, that I won't get re-elected. And if I don't, that's OK. It's not the end of the world."