David Letterman Mocks McCain Loss: "You Don't Show Up For Me, America Doesn't Show Up For You" (VIDEO)

"Attention passengers, the Straight Talk Express is no longer in service," David Letterman opened his "Late Show" monologue Wednesday night.

The late night host, who famously sparred with John McCain after the Republican candidate canceled on a scheduled appearance, only to be caught on tape filming an interview with Katie Couric at the time he was due with Letterman, then openly mocked McCain over his loss.

"I would like to say one thing to John McCain," Letterman said. "Listen, Senator: you don't show up for me, America doesn't show up for you."

Letterman also joked about the Obama transition.

"I think I speak for most Americans when I say, anybody mind if he starts a little early? Would that be a problem?"