Cheney, who accused Iran of having "one of the most radical regimes in history" and being "sworn to destroy Israel," told radio host Hugh Hewitt the deal will be a "burden" on the next occupant of the White House.
"This is a totally radical regime that is the premiere sponsor of state terrorism in the world, and Obama's about to give them nuclear weapons," Cheney said. "It's, I can't think of a more terrible burden to leave the next president than what Obama is creating here."
Cheney -- who is busy promoting his new book Exceptional: Why The World Needs a Powerful America, which he co-authored with his daughter Liz -- went on to call Obama "the worst president we've ever had."
"If you had somebody as president who wanted to take America down, who wanted to fundamentally weaken our position in the world and reduce our capacity to influence events, turn our back on our allies and encourage our adversaries, it would look exactly like what Barack Obama's doing," Cheney said.
Obama defended the Iran deal in an interview with New York Times columnist Thomas Friedman published Sunday, reaffirming the U.S.'s commitment to protecting Israel from any potential threat of an Iranian attack.
"If Israel were to be attacked by any state ... we would stand by them," Obama said. "And that, I think, should be ... sufficient to take advantage of this once-in-a-lifetime opportunity to see whether or not we can at least take the nuclear issue off the table.”
Listen to Cheney on Hewitt's show above.