The business mogul and GOP presidential candidate is a frequent target of the sketch comedy show's skewering. He's currently played by Taran Killam.
While Democratic candidate Hillary Clinton made a cameo on "SNL" earlier this month, Trump will be the first 2016 candidate to host the show.
Trump also hosted "SNL" in April 2004 during the first season of his NBC reality TV show "The Apprentice."
In June, NBC ended its business relationship with Trump over his remarks about Mexican immigrants, deciding it would no longer air the Trump-backed Miss USA and Miss Universe pageants.
"At NBC, respect and dignity for all people are cornerstones of our values," the network said in a statement. "Due to the recent derogatory statements by Donald Trump regarding immigrants, NBCUniversal is ending its business relationship with Mr. Trump."
Trump called the network "weak and foolish" in response.
Also on HuffPost: