The actor has signed on for two episodes of the Fox comedy's sophomore season as Doctor Paul Leotard, a "charismatic and popular doctor who replaces Mindy (Mindy Kaling) at Shulman & Associates while she is in Haiti on a volunteer mission."
Franco's character is a former professional model who decided to pursue a career in "helping pregnant women" after a pregnant woman saved his life when he fell off a runway.
"The Mindy Project" centers on Mindy Lahiri, a successful OB/GYN who is chronically unlucky in love, but gets by with the help of her friends and coworkers, played by Chris Messina, Ed Weeks and more.
The comedy featured many famous comedians (especially those of the Judd Apatow world) in its first season, including Seth Rogen, Allison Williams, Seth Meyers and B.J. Novak.
Kaling, Franco and Rogen recently worked together in the comedy "This Is The End." "It was a three-minute phone call," Kaling told GQ of being convinced to do the movie. "I was going to be paid to fake-socialize at a decadent fake James Franco house party and then fake-die. I have one of the better bloodcurdling screams in Hollywood, if I may say. When am I going to be able to showcase that in my various observational-comedy TV programs? Never. I was psyched."
"The Mindy Project" returns to Fox on Tues., Sept. 24 at 9:30 p.m. ET on Fox.