Prine, who influenced generations of musicians, was inducted into the Songwriters Hall of Fame last year.
In January, he was honored with a lifetime achievement Grammy, with fellow music legend Bonnie Raitt paying tribute to Prine from the stage.
He had penned one of Raitt’s best-known tunes, “Angel From Montgomery.”
Many on social media wrote “make him an angel,” a play on a line from the song:
Others quoted songs such as “When I Get To Heaven”:
But all were sharing the same thought: This one hurts.