The 27-year-old "Smallville" star resembles a reptile basking in the sun on a rock covered in merely body paint for the "Exotic Skins" PETA campaign.
With the tagline asking "Whose Skin Are You In?" the ad aims to draw attention to PETA's campaign to save reptiles, which the organization says are often killed for fashion accessories, like shoes and handbags.
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Vandervoort, who coincidentally played a lizard in the hit TV series "V," speaks about the horrific ways in which these animals are killed.
"A lot of people think that reptiles don't feel, and they do. I think everyone should keep in mind what it is they are buying and if it is really worth it to them," the 27-year-old actress says in the YouTube video posted by PETA.
PETA explains in graphic detail how these animals are killed to feed the fashion industry:
Lizards are known to live up to 33 years in the wild, but lizards killed for their skins are usually clubbed on their heads or have their spines severed with chisels as soon as they reach "marketable" size.
PETA suggests a number of ways you can achieve glamour without compromising animals:
Fake snake, moc croc, and pleather are a few realistic and luxe-looking materials that can help you achieve a great look—without wearing someone else's skin. Popular retailers such as Victoria's Secret, H&M, Overstock.com, Cole Haan, and Nike have all signed PETA's pledge never to sell exotic skins.
PETA is no stranger to raising eyebrows with its scantily clad women appearing in anti-fur campaign ads. Earlier this year, the organization sparked controversy by announcing it would launch a porn site to raise awareness of vegetarianism.
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View some of PETA's past EXPLICIT ad campaigns in the photos below: