Melatonin and how it can help you sleep better

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How melatonin can help sleep and bio time

When I travel鈥攚hich I seem to be doing a lot of these days鈥擨 use melatonin to help with jet lag (0.5 mg, ninety minutes before I want to go to sleep in my new destination, with 20 minutes of light therapy in the morning).

Jet lag can be complicated鈥攖here are many factors that influence how severely you experience jet lag, including:

路 What is your chronotype?

路 What time zone are you in?

路 Where are you going?

路 What is the direction of travel?

路 What time is your flight?

Based on the answers to these questions, jet lag can affect us all differently鈥攂ut it seems to effect almost everyone. With this in mind, let鈥檚 take an in-depth look at melatonin: the latest research, and how you can use this hormone effectively.

There are a number of hormones in the body that influence sleep鈥攂ut only one carries the nickname 鈥渢he sleep hormone.鈥 That鈥檚 melatonin. Melatonin is central to sleep, to our daily cycles of rest and activity, and to the regulation of the body鈥檚 bio rhythms. Melatonin plays an essential role in keeping our bodies functioning on our best bio time. This, in turn, has broad effects on our overall health.

What is melatonin?

Melatonin is a hormone the body produces naturally. Natural melatonin is produced primarily by the pineal gland in the brain. Melatonin has a daily bio rhythm鈥攍evels rise and fall throughout the day and night, reaching their highest levels in the evening and falling to their lowest levels in the morning. This daily melatonin bio rhythm is strongly tied to the 24-hour cycle of light and dark. This is a key reason why nighttime light exposure can be so detrimental to sleep and to health.

Dietary sources of melatonin

Can dietary choices influence melatonin levels? In recent years, there鈥檚 been increasing scientific attention to the relationship of melatonin to diet. Cherries are one food known to be naturally high in melatonin. A recent study looked at whether drinking tart cherry juice would improve melatonin levels and sleep. Among the tart cherry-juice drinkers, melatonin levels and serotonin levels rose significantly. This group also experienced significant improvements to their sleep鈥攖hey slept more, and improved their sleep efficiency. The study looked specifically Montmorency tart cherry juice. For more information about this type of cherry, check out

Some foods that are part of the Mediterranean diet are high in melatonin, including grapeseeds, tomatoes and bell peppers, and walnuts. The amino acid tryptophan is required for the body to make melatonin. Recent research indicates that eating tryptophan-rich foods may be beneficial for melatonin levels and for sleep.

Melatonin supplements

Supplemental melatonin is produced synthetically, and is most often used in pill form. Here鈥檚 some important information to know, when considering using a melatonin supplement: A recent scientific investigation found that the actual melatonin content found in many supplements on the market may vary significantly from what product labels claim. Scientists at Ontario鈥檚 University of Guelph found that in more than 71 percent of melatonin supplements, the amount of melatonin was more than 10 percent different from what the product label indicated. Some products contained as much as 83 percent less melatonin, while other products contained as much as 478 percent more melatonin. That means a great many consumers aren鈥檛 taking what they think they are, when they use a melatonin supplement. Before you begin using melatonin, be sure to do your research and get your melatonin from a trusted source.

Scientific research on the effects of melatonin on sleep and health have been underway since the discovery of the hormone in 1958. In 1994, the first melatonin supplements became available.

How does melatonin work?

Melatonin production in the body is triggered by darkness and suppressed by light. The brain receives light and dark cues through the retina of the eye, which are then communicated along the optic nerve to the brain鈥檚 master bio clock, the superchiasmatic nucleus, or SCN. This bio clock controls the flow of melatonin and other hormones鈥攁s well as a vast array of other physiological processes.

When it鈥檚 dark, the SCN gives the go-ahead to the pineal gland to ramp up its production of melatonin. Typically, melatonin levels begin to rise significantly around 9 p.m., and peak during the overnight hours before falling to very low levels shortly before dawn. Melatonin stays low throughout the daylight hours, as other hormones rise to help maintain focus, energy, and alertness throughout the day.

The length of melatonin production shifts throughout the year, with shorter daily periods of melatonin production in the summer when days are longer, and longer periods in the winter, when nights are longer. Melatonin production decreases with age, which may contribute to increased sleep problems, as well as to overall aging and vulnerability to disease.

Disruptions in natural melatonin levels can go hand-in-hand with sleep problems.

Benefits of melatonin

Melatonin, healthy sleep, and bio time

Melatonin is not a sedative. Instead, it works to promote sleep by helping to regulate the body鈥檚 bio clock and sleep-wake cycles. Scientific research shows that melatonin may help to strengthen and improve sleep-wake cycles, making it possible to adhere to more healthful sleep patterns and making it easier to sleep on a regular schedule. Research indicates that melatonin may shorten the time it takes to fall asleep, and increase overall sleep amounts. Melatonin also may improve the quality of sleep and reduce daytime sleepiness and fatigue. Studies also show melatonin may increase REM sleep.

When you sleep better and your bio clock is running in sync, it can help improve your mood, daytime performance, energy levels and your overall health, including immune function, and regulation of metabolism, digestion, and appetite.

In addition to strengthening the body鈥檚 bio clock and sleep-wake cycles, specific sleep problems that scientific research shows may benefit from supplemental melatonin include:

路 Insomnia

路 Sleep problems associated with shift work

路 Sleep problems associated with other medical conditions, such as high blood pressure, and ADHD

路 Sleep problems associated with menopause

路 Restless leg syndrome

路 Jet lag

路 Sleep problems in children with autism and other developmental disorders

路 Reduced REM sleep

路 Circadian rhythm disorders in the blind

Melatonin, brain health, and beyond

In recent years, we鈥檝e learned a lot about the power of melatonin as an antioxidant and about its impact on healthy brain function. Increasingly, melatonin is considered able to play an important role in protecting against cognitive impairment and neurodegenerative disease that come about from age and also from injury.

As an antioxidant, melatonin may work to protect against cell damage. Oxidative damage to brain cells is believed to be a prime factor in age-related cognitive problems, and to neurodegenerative diseases such as Alzheimer鈥檚 disease and others. Melatonin functions as a powerful antioxidant in the brain鈥攂ut its antioxidant capabilities are not limited to the brain. As an antioxidant, melatonin appears to have protective effects over the cardiovascular system and other physiological systems as well. Recent research shows that melatonin may exert its protective, antioxidant effect over neural cells, helping to delay or prevent cognitive impairment and memory loss.

Melatonin also may be effective in helping to lower high blood pressure, according to research.

Melatonin and cancer therapy

One exciting area of study for melatonin involves its potential in treating some forms of cancer. Melatonin has been shown to slow the growth of some types of cancerous tumors, and is being investigated as a possible therapy for several different types of cancer. According to research, melatonin may also be effective in treating the side effects of other cancer treatments, including chemotherapy.

Melatonin and autism spectrum disorders

Many children and adults with autism spectrum disorder, or ASD, have trouble sleeping. Scientific research has found that people with autism spectrum disorders may have abnormalities to their natural melatonin levels. Research suggests people with ASD may have lower concentrations of nighttime melatonin. Some studies have also found correlations between abnormal melatonin levels and the severity of ASD symptoms. Supplemental melatonin may be effective at improving sleep quality and sleep quantity in people with ASD, and also may help improve daytime behavior.

Other possible uses for melatonin

Our understanding of melatonin is expanding rapidly, as scientists continue to study how the hormone works in the body, how it contributes to health and disease protection, and how melatonin may be used as a therapeutic treatment. The effectiveness of melatonin is being investigated for several other medical conditions, including:

路 Age-related macular degeneration

路 Chronic Fatigue Syndrome (CFS)


路 Irritable bowel syndrome

路 Menopause symptoms

路 Metabolic syndrome

路 Migraine and other types of headache

Melatonin: what to know

Always consult your doctor before you begin taking a supplement or make any changes to your existing medication and supplement routine. This is not medical advice, but it is information you can use as a conversation-starter with your physician at your next appointment.

Melatonin dosing

The following doses are based on amounts that have been investigated in scientific studies. In general, for sleep problems it is recommended that users begin with the smallest suggested dose, and gradually increase until it has an effect.

For regulation of sleep-wake cycles: 0.3mg to 5 mg

For insomnia: 2-3 mg; in some research, higher doses have been used for short-term use

For jet lag: 0.5 mg to 8 mg, starting upon day of arrival at destination

For sleep-wake cycle disruptions: 2mg to 12mg

For delayed sleep phase syndrome: 3-5mg

For sleep and sleep-wake cycle disruptions in the blind: 0.5mg to 5 mg

The half life of melatonin is between 20-50 minutes. Half-life refers to the amount of time it takes for a supplement or medication to reduce its concentration by 50 percent once in the body.

Possible side effects of melatonin

Generally, melatonin is well tolerated by healthy adults. There are possible side effects of from melatonin, including headaches, daytime sleepiness, dizziness, stomach irritation or cramping, irritability and short-term depression. Because of the potential for dizziness and sleepiness, people it is recommended that people not drive within five hours of taking melatonin.

People with the following conditions should consult with a physician before beginning to use a melatonin supplement:

路 Pregnancy, and women who are breast feeding (It is recommended that women who are pregnant or breast feeding not use melatonin.)

路 Bleeding disorders

路 Depression

路 Diabetes

路 High blood pressure

路 Seizure disorders

路 Transplant recipients

Melatonin interactions

The following medications and other supplements may interact with melatonin. Effects may include increasing or decreasing the amount of melatonin in the body, interfering with the effectiveness of the medications or supplements, and interfering with the condition that is being treated by the medication or supplement. This is a list of commonly used medications and supplements that have scientifically identified interactions with melatonin. People who take these or any other medications and supplements should consult with a physician before beginning to use a melatonin supplement.

Interactions with medications

路 Anticonvulsant and other seizure-related medications

路 Antidepressant medications

路 Antipsychotic medications

路 Anticoagulant medications

路 Beta-blockers

路 Contraceptive medications

路 Diabetes medications

路 High blood pressure medications

路 Immunosuppressant medications

路 Non-steroidal anti-inflammatory (NSAID) medications

路 Sedative medications

路 Medications that are altered or broken down by the liver

Interactions with other supplements

路 Caffeine

路 Echinacea

路 Supplements that target high blood pressure (andrographis, casein peptides, cat鈥檚 claw, coenzyme Q-10, fish oil, L-arginine, lyceum, stinging nettle, theanine, and others)

路 Supplements that may lower seizure threshold (butanediol, cedar leaf, Chinese club moss, EDTA, folic acid, GBL, GHB, glutamine, huperzine A, hydrazine sulfate, hyssop oil, juniper, L-carnitine, rosemary, sage, wormwood and others)

路 Supplements that may reduce blood clotting (angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, will and others)

路 Supplements that may function as sedatives (5-HTP, calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John鈥檚 wort, skullcap, valerian, yerba mansa and others)

路 Vitamin B 12

How melatonin can work with your chronotype

All four chronotypes may benefit from using melatonin to help strengthen and regulate sleep-wake cycles, and improve sleep. The best time to take melatonin will differ from chronotype to chronotype. Lions will tend to take melatonin earlier in the evenings than other chronotypes, while Wolves and Dolphins will need to take melatonin later than Lions and Bears. The best time to take a melatonin supplement is about 30 minutes to 1 hour before bedtime.

Melatonin is one of the most important hormones in the body, essential to sleep and to overall health. This 鈥渟leep hormone鈥 has a role in a great deal more than sleep鈥攁nd may prove to be an increasingly versatile therapy to fight aging and disease.

Sweet Dreams,

Michael J. Breus, PhD

The Sleep Doctor鈩

Alzoubi, KH, et al. (2016). Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation. Molecular Neurobiology, 53(5): 3439-3447. Retrieved from:

American Academy of Sleep Medicine. (2017, February 14). Melatonin content of supplements varies widely, study finds: Results highlight the need for improved quality control of melatonin supplements. ScienceDaily. Retrieved from:

Besedorksky, L, et al. (2012). Sleep and immune function. Pflugers Archiv, 463(1): 121-137. Retrieved from:

Bubenik, GA & Konturek, SJ. (2011). Melatonin and aging: prospects for human treatment. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 62(1):13-9. Retrieved from:

Buscemi, N, et al. (2012). The efficacy and safety of exogenous melatonin for primary sleep disorders: A meta-analysis. Journal of general internal medicine, 20(12):1151-8. Retrieved from:

Chowdhury, I, et al. (2008). Melatonin: 50 years of scientific journey from the discovery in bovine pineal gland to delineation of function in humans. Indian journal of biochemistry + biophysics, 45(5):289-304. Retrieved from:

Cutando, A, et al. (2012). Role of melatonin in cancer treatment. Anticancer Research, 32(7):2747-53. Retrieved from:

Howatson, G, et al. (2012). Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. European journal of nutrition, 51(8)906-916. Retrieved from:

Iriti, M & Varoni, EM. (2015). Melatonin in Mediterranean diet, a new perspective. Journal of the science of food and agriculture, 95(12):2355-9. Retrieved from:

Kunz, D, et al. (2004). Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. The journal of clinical endocrinology and metabolism, 89(1):128-34. Retrieved from:

Michigan State University (2016, August 23). Melatonin boost a key to fighting breast cancer. Science Daily. Retrieved from:

National Sleep Foundation. Melatonin and Sleep. Retrieved from:

Natural Medicines Therapeutic Research. Melatonin. (2017, May 3). Retrieved from:

Palm, L, et al. (1997). Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. Developmental medicine and child neurology, 35(5):319-25. Retrieved from:

Peuhkuri, K, et al. (2012). Diet promotes sleep duration and quality. Nutrition Research, 32(5): 309-319. Retrieved from:

Peuhkuri, K, et al. (2012). Dietary factors and fluctuating levels of melatonin. Food & Nutrition Research, 56. Retrieved from:

Reiter, RJ, et al. Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition, 21(9):920-4. Retrieved from:

Riga, P, et al. Melatonin content of pepper & tomato fruits: effects of cultivar and solar radiation. Food Chemistry, 156:347-52. Retrieved from:

Rossignol, DA & Frye, RE. (2014). Melatonin in autism spectrum disorders. Current Clinical Pharmacology, 9(4):326-34. Retrieved from:

Sargis, RM. (2014, June 10). An Overview of the Pineal Gland: Maintaining Circadian Rhythm. Retrieved from:

Scheer, FA, et al. (2004). Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension, 43(2):192-7. Retrieved from:

Schrag, M, et al. (2013). Oxidative stress in blood in Alzheimer鈥檚 disease and mild cognitive impairment: A meta-analysis. Neurobiology of Disease, 59:100-110. Retrieved from:

Seithikurippu, R, et al. Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes. Neurotoxicity Research, 23(3):267-300. Retrieved from:

Sharma, S & Kavuru M. (2010). Sleep and Metabolism: An Overview. International Journal of Endocrinology, 2010:270832. Retrieved from:

Touitou, Y., et al. (2017). Association between light at night, melatonin secretion, sleep deprivation and the internal clock: health impacts and mechanisms of circadian disruption. Life Sciences, 173: 94-106. Retrieved from:

University of Maryland Medical Center. Melatonin. (2016, February 3). Retrieved from:

Vitalini, S. et al. (2011). The presence of melatonin in grapevine (vitis vinifera L) berry tissues. Journal of Pineal Research, 51(3):331-7. Retrieved from:

Wurtman, RJ. (2000). Age-Related Decreases in Melatonin Secretion鈥擟linical Consequences. The Journal of Clinical Endocrinology & Metabolism, 85(6):2135-2136. Retrieved from:

Zhang, HM & Zhang, Y. (2014). Melatonin: a well-documented antioxidant with conditional pro-oxidant actions. Journal of Pineal Research, 57(2):131-46. Retrieved from:

Zhang, L, et al. (2013). Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF, and CaMKII. Behavioral Brain Research, 256:72-81. Retrieved from: