The famed scientist and author gives an answer that is perhaps as eloquent as it is mind-blowing; as beautiful as it is sublime.
It's best to hear Tyson's response in the video, but his answer is perhaps best revealed in one particular quote:
"We are part of this universe; we are in this universe, but perhaps more important than both of those facts, is that the universe is in us," he explains.
"Many people feel small because they're small and the universe is big, but I feel big," he says.
In the clip above, video editor Max Schlickenmeyer ties the insights together with breathtaking visuals to create a powerful representation of the science behind Tyson's answer .
Learn more about Tyson's revelation by watching the video above and the full interview below. Afterwards, be sure to share your reaction in the comments section.
WATCH: Time magazine's interview with Neil deGrasse Tyson: