Not even if former House Speaker John Boehner (R-Ohio) endorses him? No, not even then.
"The speaker is grateful for the support, but he is not interested," Ryan's spokeswoman, AshLee Strong, said Wednesday in an email. "He will not accept a nomination and believes our nominee should be someone who ran this year."
Boehner had said earlier Wednesday that he would back Ryan if a clear nominee didn't emerge.
"If we don't have a nominee who can win on the first ballot, I'm for none of the above," Boehner said while speaking at the Futures Industry Association conference in Florida, according to Politico.
"They all had a chance to win," he continued. "None of them won. So I'm for none of the above. I'm for Paul Ryan to be our nominee."
But Boehner's off-the-cuff comments weren't entirely serious, a spokesman told Bloomberg. The former speaker supports fellow Ohioan Gov. John Kasich in his bid for the White House.
This post has been updated to note Ryan's change of heart regarding the speakership.