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Antibiotics, Obesity and You

The discovery of antibiotics is celebrated for the profound impact they have had on modern medicine and is a reminder of the role luck plays in science. There is no argument that antibiotics have saved millions of lives over the past 87 years, but there is a downside, too.
09/17/2015 04:00pm ET | Updated September 17, 2016
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This week, we celebrate Alexander Fleming's Nobel Prize-winning discovery of penicillin. The discovery of antibiotics is celebrated for the profound impact they have had on modern medicine and is a reminder of the role luck plays in science. There is no argument that antibiotics have saved millions of lives over the past 87 years, but there is a downside, too.

Antibiotics are effective for curing acute bacterial infection, but indiscriminate use may also have profound negative effects on our long-term health. More than 70 percent of antibiotics are consumed in factory farming of animals. Our government has been anemic in addressing this threat. In December 2013, the FDA offered voluntary guidance for pharmaceutical companies that suggested a three-year phase-out of antibiotics in animal feed, a practice known as "growth promotion." This guidance does not go far enough. The use of antibiotics for factory farming is still widespread, even as some of the largest food manufacturers and restaurant chains have limited the use of antibiotics in their supply chain (Tysons, Perdue, McDonald's, Chick-fil-A, Chipotle).

The need to curb antibiotic use is an urgent and increasingly complex problem, but not only because of antibiotic resistance. We are learning ever more about the integral benefits of the trillions of bacteria we all harbor in our gut. This microbiome works synergistically with its human host to maintain health and wellbeing. Imbalance or loss of diversity of gut bacteria is now thought to influence mental health, autoimmune disease, and a whole host of other chronic problems. In fact, it is entirely possible that antibiotics have had a profound effect on the obesity epidemic. We know that when antibiotics are added to their feed, farm animals get fatter. Further, scientists can induce obesity in mice by transplanting gut bacteria.

The healthy diversity of bacteria in our gut has been compared to a rain forest. Clear-cutting the forest decreases its diversity so that it resembles a multi-crop farm. Similarly, every time we take an antibiotic for an acute infection (or to prevent an infection), we are remodeling the balance of bacteria in our body. Individuals should understand the impact that antibiotics have on this delicate ecosystem, and should discuss with their physician how integral the use of antibiotics are in their current treatment.

We need a two-pronged approach to this problem. First, we need to encourage our govern-ment representatives to promote legislation that removes antibiotics from our food supply. Second, we need greater funding focused on human microbiome research to understand the role gut bacteria play in health and disease. Findings from the NIH's Human Microbiome Project, The David Lab at Duke University and other similar labs around the world are crit-ical in eradicating some of today's most vexing diseases. Individuals can help by donating samples to the American Gut Project or uBiome or by contributing to charities such as the Crohn's and Colitis Foundation that are conducting active research in this area.

So, on this anniversary of penicillin, we should all be thankful for the scientific discoveries that have made it possible to relieve suffering. But we must also remain mindful of the complexity of the human body. Altering a single pathway of such a complex system, as occurs with antibiotic use, is sure to have unintended effects. This reinforces the importance of a holistic approach to medicine, which considers the whole patient rather than reducing their condition to an isolated problem.

One thing is clear, however -- Alexander Fleming's work continues to impact modern medicine 87 years later.

Jeffrey M. Taekman, M.D.
Professor of Anesthesiology
Assistant Dean for Educational Technology
Director, Human Simulation and Patient Safety Center
Faculty, Duke Center for Health Informatics
Duke University School of Medicine