Rosie O'Donnell's New Show To Tape At Oprah's Harpo Studios

Oprah Winfrey may be leaving town, but her Harpo Studio One will not be vacant.

Harpo executives announced Tuesday that Rosie O'Donnell will begin taping her new, nationally syndicated talk show in the West Side studio this fall. The one-hour show will air on OWN: The Oprah Winfrey Network.

"Hello people of Harpo, it's me, Rosie O'Donnell, star of 'The Flintstones,'" O'Donnell said in a video message. "I just wanted to say: Hi, I'm coming to Chicago. Yes, I am, and I'm thrilled about it. And I get to work with all of you, who have created magnificent television for two decades-plus."

Winfrey issued a statement welcoming O'Donnell to Harpo, according to the Chicago Tribune.

"Speaking from experience, she will be working with the best team in television in one of the greatest cities in the world," she said.

The Sun-Times explains what the new show will focus on:

O'Donnell told O magazine that her new show will be less celebrity-driven. "The show will be about real people and real issues," she said. "I'll focus on a single topic for one hour, things people deal with every day. Raising children. The education system in America. Autism. Relationships, health, weight, depression -- and happy stuff too, of course. I envision the show being full of love and laughter."

The final original episode of Winfrey's show is scheduled to air May 25.