The couple's representative told ABC News that they have "been living apart for months…and remain good friends and partners."
Brin, who has two children with Wojcicki, is rumored to be romantically involved with another Google executive, although he did not comment on that relationship.
As ABC News pointed out, Brin is considered by Forbes to be the 14th richest person in America, with an estimated wealth of $22.8 billion. And if Brin and his wife do move forward with a divorce, he will join the ranks of many other divorcés on that elite list.
Rupert Murdoch, who is ranked number 33 on Forbes' list, , announced his divorce from wife Wendi Deng in June 2013. And Harold Hamm, number 32 on the list of richest people in America, stands to lose up to $5 billion in his ongoing divorce.
Click through the slideshow below to see which other billionaires have divorced their spouses.