“I’m not a doctor,” Colbert said on Monday. “But I’m pretty sure it’s not a good sign when you get prescribed the high score in a Scrabble game.”
Then, Colbert took a look at the medications’ side effects, which for dexamethasone include “a feeling of extreme well-being” and “temporary burning, pain and itching around your anus.”
Colbert used that as a chance to play a clip of Johnny Cash performing “Ring of Fire” as a testimonial to the drug. That one unusual side effect also became a running gag that burned through the rest of his monologue:
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