The lieutenant governor joins a packed Democratic primary in what will be one of the most hotly contested Senate races of the 2022 cycle.
Miles Taylor also warns of what could happen if Republicans retake the House.
GOP Senate candidates across the country are hoping the former president forgets their past attacks.
The agriculture commissioner will battle ex-Gov. Charlie Crist for the Democratic nomination.
"The residents in our district deserve a fighter," the second-time Chicago candidate said.
Democratic campaign vets have started the "Never Again PAC" to help defeat the 147 members of Congress who voted to reject the election result in Trump's favor.
Anthony Bouchard is challenging Rep. Liz Cheney for her seat in the House.
Rubio's reelection could hinge on whether Florida Republicans love Trump more than Florida Democrats hate him.
The 35-year-old candidate for New York governor claimed he has spent parts of five decades in politics.
The congresswoman had been weighing whether to run for the Florida governorship or a seat in the Senate.