Government officials claim insurgents were behind the gas attack, but rebel groups have called the allegations "purely a lie."
The attack in February left 11 people in need of emergency treatment.
“Could not have had a better result,” said President Donald Trump. “Mission Accomplished!”
The strikes, led by the U.S., U.K. and France, targeted three facilities associated with Syria’s chemical weapons program.
Kassem Eid, a Palestinian Syrian rebel, called on U.N. Ambassador Nikki Haley to resign over Saturday's massacre.
Several western countries including the U.S. denied any involvement.
He also criticized Obama for not ending Syria's violent conflict "long ago."
A chemical attack on a rebel-held town in eastern Ghouta was said to have killed at least 49.
The new sanctions are the most significant the U.S. has taken against Russia since Trump took office.
At his daily briefing, press secretary Sean Spicer says Hitler did not use chemical weapons in World War II.