Christina Applegate(01 of19)
Open Image ModalUS actress Christina Applegate arrives on the Burgundy carpet for the UK Premiere of Anchorman 2: The Legend Continues, at a central London cinema, Wednesday, Dec. 11, 2013. (Photo by Joel Ryan/Invision/AP) (credit:AP)
Christina Applegate(02 of19)
Open Image ModalUS actress Christina Applegate arrives on the Burgundy carpet for the UK Premiere of Anchorman 2: The Legend Continues, at a central London cinema in Leicester Square, Wednesday, Dec. 11, 2013. (Photo by Joel Ryan/Invision/AP) (credit:AP)
Will Ferrell, Christina Applegate(03 of19)
Open Image ModalWill Ferrell and Christina Applegate film "Anchorman: The Legend Continues" on Saturday, May 18, 2013 in New York. (Photo by Charles Sykes/Invision/AP) (credit:AP)
Christina Applegate(04 of19)
Open Image ModalActress Christina Applegate poses at the Light Up The Blues Concert - An Evening of Music Benefitting Autism Speaks, at Club Nokia on Saturday, April 13, 2013 in Los Angeles. (Photo by Chris Pizello/Invision/AP) (credit:AP)
Up All Night - Season 2(05 of19)
Open Image ModalThis undated publicity photo released by NBC shows Christina Applegate, as Reagan Brinkley, in the TV series, "Up All Night," Season 2, "The Wedding," Episode 211. Applegate says she's bowing out of NBC's "Up All Night." In a statement Friday, Feb. 8, 2013, the actress said the show has taken a "different creative direction" and she's decided to move on to other projects. She called the sitcom a great experience and said she will miss her co-workers. (AP Photo/NBC, Colleen Hayes) (credit:AP)
Christina Applegate(06 of19)
Open Image Modal"Up All Night" cast member Christina Applegate arrives for the NBC network upfront presentation at Radio City Music Hall, Monday, May 14, 2012 in New York. (AP Photo/Evan Agostini) (credit:AP)
Christina Applegate(07 of19)
Open Image ModalFILE - This Aug. 1, 2011 file photo shows actress Christina Applegate, a cast member in the television series "Up All Night," taking part in a panel discussion on the show at the NBC Universal summer press tour in Beverly Hills, Calif. Applegate, 40, was diagnosed with breast cancer at age 36 and underwent a double mastectomy. To help raise money during Breast Cancer Awareness month for her Right Action for Women charity, Applegate will wear the sneakers, headbands and jog bra that sportswear brand ASICS has made as fundraising items in a special-edition partnership. The items are on sale through Oct. 31. (AP Photo/Chris Pizzello, file) (credit:AP)
Christina Applegate(08 of19)
Open Image ModalActress Christina Applegate arrives at the NBC TCA All-Star Party in Los Angeles on Monday, Aug. 1, 2011. (AP Photo/Dan Steinberg) (credit:AP)
Christina Applegate Visits "Late Night With Jimmy Fallon"(09 of19)
Open Image ModalNEW YORK, NY - OCTOBER 11: Actress Christina Applegate visits 'Late Night With Jimmy Fallon' at Rockefeller Center on October 11, 2012 in New York City. (Photo by Jamie McCarthy/Getty Images) (credit:Getty Images)
Christina Applegate, Martyn Lenoble(10 of19)
Open Image ModalIn this July 19, 2010 photo, actress Christina Applegate arrives with her husband Martyn Lenoble at the 2010 VH1 Do Something Awards in Los Angeles. (AP Photo/Chris Pizzello) (credit:AP)
NBCUniversal's "Up All Night" TCA Set Visit(11 of19)
Open Image ModalSTUDIO CITY, CA - JULY 31: Actors Christina Applegate and Will Arnett attend NBCUniversal's 'Up All Night' TCA set visit at CBS Studios - Radford on July 31, 2012 in Studio City, California. (Photo by Alberto E. Rodriguez/Getty Images) (credit:Getty Images)
NBCUniversal's "Up All Night" TCA Set Visit(12 of19)
Open Image ModalSTUDIO CITY, CA - JULY 31: Actress Christina Applegate attends NBCUniversal's 'Up All Night' TCA set visit at CBS Studios - Radford on July 31, 2012 in Studio City, California. (Photo by Alberto E. Rodriguez/Getty Images) (credit:Getty Images)
NBCUniversal's "Up All Night" TCA Set Visit(13 of19)
Open Image ModalSTUDIO CITY, CA - JULY 31: Executive Vice President of Universal Media Studios Bela Bajaria, actress Christina Applegate and actress actress Maya Rudolph attend NBCUniversal's 'Up All Night' TCA set visit at CBS Studios - Radford on July 31, 2012 in Studio City, California. (Photo by Alberto E. Rodriguez/Getty Images) (credit:Getty Images)
LG Electronics Hosts '20 Magic Minutes: A Family Celebration'' To Launch The New Mega-Capacity TurboWash Washer(14 of19)
Open Image ModalBEVERLY HILLS, CA - JUNE 23: Actress Christina Applegate attends '20 Magic Minutes: A Family Celebration' To Launch The New Mega-Capacity TurboWash Washer hosted by LG Electronics on June 23, 2012 in Beverly Hills, California. (Photo by Alberto E. Rodriguez/Getty Images for LG) (credit:Getty Images)
Actress Christina Applegate arrives at W(15 of19)
Open Image ModalActress Christina Applegate arrives at Women in Film Presents The 2012 Crystal + Lucy Awards in Los Angeles, California, on June 12, 2012. AFP PHOTO/VALERIE MACON (Photo credit should read VALERIE MACON/AFP/GettyImages) (credit:Getty Images)
NBC's Upfront Presentation(16 of19)
Open Image ModalNEW YORK, NY - MAY 14: Actress Christina Applegate attends NBC's Upfront Presentation at Radio City Music Hall on May 14, 2012 in New York City. (Photo by Jemal Countess/Getty Images) (credit:Getty Images)
The Paley Center For Media Presents An Evening With "Up All Night"(17 of19)
Open Image ModalBEVERLY HILLS, CA - MAY 08: Actors Will Arnett and Christina Applegate arrive at The Paley Center For Media presents an evening with 'Up All Night' at The Paley Center for Media on May 8, 2012 in Beverly Hills, California. (Photo by Frazer Harrison/Getty Images) (credit:Getty Images)
The Paley Center For Media Presents An Evening With "Up All Night"(18 of19)
Open Image ModalBEVERLY HILLS, CA - MAY 08: Actress Christina Applegate arrives at The Paley Center For Media presents an evening with 'Up All Night' at The Paley Center for Media on May 8, 2012 in Beverly Hills, California. (Photo by Frazer Harrison/Getty Images) (credit:Getty Images)
The Paley Center For Media Presents An Evening With "Up All Night"(19 of19)
Open Image ModalBEVERLY HILLS, CA - MAY 08: Actors Maya Rudolph and Christina Applegate, arrive at The Paley Center For Media presents an evening with 'Up All Night' at The Paley Center for Media on May 8, 2012 in Beverly Hills, California. (Photo by Frazer Harrison/Getty Images) (credit:Getty Images)