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Our Teens Could Be Facing A Dangerous Post-Antibiotic Future

A need exists for rapid change in the social mindset of the next generation on antibiotics. If our youth do not appreciate the challenges facing public health officials today, they may end up living under the shadow of untreatable bacterial infections known as the post-antibiotic era.
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There's a common belief the actions of our youth today dictate what will happen in the future. In many ways this is true, but usually only on at the personal and local levels. When it comes to major global changes, we tend to give this statement less credence. After all, worldwide changes take time and may require several generations to achieve.

There is one exception to this rule in the global health community. A need exists for rapid change in the social mindset of the next generation on antibiotics. If our youth do not appreciate the challenges facing public health officials today, they may end up living under the shadow of untreatable bacterial infections known as the post-antibiotic era.

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This requirement makes perfect sense. Unfortunately, figuring out how to get younger individuals to pay attention and heed the recommendations requires far more than some quick thinking. A plan must be in place in order to reach them and ensure they understand the stakes.

At one time, this might have been easy facilitated through educational videos, pamphlets, and discussions in schools. But that has changed thanks to modern technological communication. Attention spans have decreased significantly and traditional methods are becoming obsolete. Without modern educational strategies is in place, the youth cannot be expected to know or even care about the plight of these potentially life-saving drugs.

Before any policies can be made, however, we need to know about the perceptions of youth regarding antibiotics. While we may suspect they have little to no knowledge or concern about antibiotic resistance, we need to know whether this theory is correct. But these types of studies simply do not exist making any attempt at developing plans for action potentially useless.

Last week, we finally attained a glimpse of the youth view on antibiotics and resistance. It was due to a UK group of researchers who undertook an examination of the perceptions of British teenagers on the topic of antibiotics in respiratory illness and resistance. The results of the study confirmed the theories as well as opened our eyes to unanticipated problems moving forward.

The majority - save for those taking science courses - did not know antibiotics are used solely for bacterial infections.

The team talked with 74 teenagers between the ages of 16 and 18. The volunteers participated in focus groups and also one-on-one interviews. The topics included such items as the individuals' history of taking antibiotics, perceptions of antibiotics, management of respiratory infections particularly colds and the flu, the choice of self-care in place of a doctor, and finally, antimicrobial resistance. The students were allowed to express their views freely without any biased response from the interviewers.

When the results came back, it was clear the students knew antibiotics were treatments for infections. However, the majority -- save for those taking science courses -- did not know antibiotics are used solely for bacterial infections. This aligned with the realization most students did not know the difference between a bacterial and viral infection.

While this information was expected to some extent, there were some surprises in store. In some cases, students equated antibiotics to painkillers. This was a rather troublesome finding suggesting more needs to be done to demonstrate the uniqueness of antibiotics as a medical treatment. In addition, the students had a less than trusting view of their parents. At best, the adults were advisers on health; at worst, they knew less than the students themselves. This suggested any attempts at using parents to influence their kids would most likely end up failing.

When it came to the major topic of interest, resistance, the results revealed teenagers had a sense of what antibiotic resistance meant but the phenomenon did not affect them. The topic was not a concern to them or their peers. They also did not equate the link between personal antibiotic use and the coming post-antibiotic era. The decision lied solely in the hands of the physician. This was due in part to the belief new antibiotics will always surface. While the participants understood this process would take time, they did not appreciate the reality of fewer drugs in the pipeline.

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The results of this study reveal a rather bumpy road ahead for public health officials. Clearly, misinformation abounds. This is due in part to the absence of proper education in schools (apart from science courses), a lack of trust in parental guidance, and an overall apathy towards antibiotic resistance. As to paths to remediate this situation, they are limited at best.

Finding a direction forward no doubt requires some type of intervention to improve teens' knowledge of antibiotics and resistance. The best place for this may be in schools in areas outside of traditional science classes. Events such as assemblies, class visits from experts, and artistic competitions all may serve to improve knowledge in these individuals.

There is also a government option to help in this cause. Antibiotic resistance should be considered a priority for ministries dealing with youth. Inasmuch as exercise, diet and mental health are important, for the sake of our future, antibiotics and the rise in resistance should be given proper attention. Not to mention, a universal message can improve the situation nationwide.

As to when these programs should be implemented, the answer is simple: as soon as possible. With increasing reports of multi-drug and pan-resistance, the clock continues to tick towards a post-antibiotic era. If we do not engage action in our youth now, the future of our health will be rather dismal as it will be dictated by bacterial pathogens.

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Current Antibiotic Threats in the U.S.
CRE (carbapenem-resistant Enterobacteriaceae)(01 of18)
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CRE, carbapenem-resistant Enterobacteriaceae, are the “nightmare bacteria” we reported on in March. These include bacteria that can resist all antibiotics, kill a high number of people who get it in their blood, and spread their resistance capabilities to other bacteria. (credit:CDC)
Clostridium difficile(02 of18)
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C.difficile, a life-threatening infection causing deadly diarrhea, causes at least 250,000 hospitalizations and 14,000 deaths each year. Although not significantly resistant itself, C. difficile infections usually happen to people who are taking or who recently took antibiotics, or who caught the infection from those who did. (credit:CDC)
Drug-resistant Neisseria gonorrhoeae(03 of18)
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Thirty percent of gonorrhea infections are caused by microbes resistant to at least one antibiotic. If gonorrhea becomes resistant to antibiotics called cephalosporins, there could be an estimated 75,000 additional cases of pelvic inflammatory disease, a major cause of infertility. I’ve taken care of patients with infected joints from gonorrhea which has spread – a complication that can be disabling, painful, and expensive to treat. (credit:CDC)
Multidrug-resistant Acinetobacter(04 of18)
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Acinetobacter is a type of gram-negative bacteria that is a cause of pneumonia or bloodstream infections among critically ill patients. Many of these bacteria have become very resistant to antibiotics. (credit:CDC)
Drug-resistant Campylobacter(05 of18)
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Campylobacter usually causes diarrhea (often bloody), fever, and abdominal cramps, and sometimes causes serious complications such as temporary paralysis. (credit:CDC)
Fluconazole-resistant Candida(06 of18)
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Candidiasis is a fungal infection causes by yeasts of the genus Candida. Candida is the fourth most common cause of healthcare-associated bloodstream infections in the United States. In some hospitals it is the most common causes. These infections tend to occur in the sickest patients. (credit:CDC)
Extended spectrum β-lactamase producing Enterobacteriaceae(07 of18)
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Extended-spectrum β-lactamase is an enzyme that allows bacteria to become resistant to a wide variety of penicillins and cephalosporins. Bacteria that contain this enzyme are known as ESBLs or ESBLproducing bacteria. ESBL-producing Enterobacteriaceae are resistant to strong antibiotics including extended spectrum cephalosporins. (credit:CDC)
Vancomycin-resistant Enterococcus(08 of18)
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Enterococci cause a range of illnesses, mostly among patients receiving healthcare, but include bloodstream infections, surgical site infections, and urinary tract infections. (credit:CDC)
Multi-drug resistant Psedomonas Aeruginosa(09 of18)
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Pseudomonas aeruginosa is a common cause of healthcare-associated infections including pneumonia, bloodstream infections, urinary tract infections, and surgical site infections. (credit:CDC)
Drug-resistant non-typhoidial Salmonella(10 of18)
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Non-typhoidal Salmonella (serotypes other than Typhi, Paratyphi A, Paratyphi B, and Paratyphi C) usually causes diarrhea (sometimes bloody), fever, and abdominal cramps. Some infections spread to the blood and can have life-threatening complications. (credit:CDC)
Drug-resistant Salmonella Serotype Typhi(11 of18)
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Salmonella serotype Typhi causes typhoid fever, a potentially life-threatening disease. People with typhoid fever usually have a high fever, abdominal pain, and headache. Typhoid fever can lead to bowel perforation, shock, and death. (credit:CDC)
Drug-resistant Shigella(12 of18)
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Shigella usually causes diarrhea (sometimes bloody), fever, and abdominal pain. Sometimes it causes serious complications such as reactive arthritis. High-risk groups include young children, people with inadequate handwashing and hygiene habits, and men who have sex with men. (credit:CDC)
Methicillin-resistant Staphylococcus aureus(13 of18)
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Methicillin-resistant Staphylococcus aureus (MRSA) causes a range of illnesses, from skin and wound infections to pneumonia and bloodstream infections that can cause sepsis and death. Staph bacteria, including MRSA, are one of the most common causes of healthcare-associated infections. (credit:CDC)
Drug-resistant Streptococcus pneumoniae(14 of18)
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Streptococcus pneumoniae (S. pneumoniae, or pneumococcus) is the leading cause of bacterial pneumonia and meningitis in the United States. It is also a major cause of bloodstream infections and ear and sinus infections. (credit:CDC)
Drug-resistant Tuberculosis(15 of18)
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Tuberculosis (TB) is among the most common infectious diseases and a frequent cause of death worldwide. TB is caused by the bacteria Mycobacterium tuberculosis (M. tuberculosis) and is spread most commonly through the air. M. tuberculosis can affect any part of the body, but disease is found most often in the lungs. In most cases, TB is treatable and curable with the available first-line TB drugs; however, in some cases, M. tuberculosis can be resistant to one or more of the drugs used to treat it. Drug-resistant TB is more challenging to treat — it can be complex and requires more time and more expensive drugs that often have more side effects. Extensively Drug-Resistant TB (XDR TB) is resistant to most TB drugs; therefore, patients are left with treatment options that are much less effective. The major factors driving TB drug resistance are incomplete or wrong treatment, short drug supply, and lack of new drugs. In the United States most drug-resistant TB is found among persons born outside of the country. (credit:CDC)
Vancomycin-resistant Staphylococcus aureus(16 of18)
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Staphylococcus aureus is a common type of bacteria that is found on the skin. During medical procedures when patients require catheters or ventilators or undergo surgical procedures, Staphylococcus aureus can enter the body and cause infections. When Staphylococcus aureus becomes resistant to vancomycin, there are few treatment options available because vancomycin-resistant S. aureus bacteria identified to date were also resistant to methicillin and other classes of antibiotics. (credit:CDC)
Erythromycin-resistant Group A Streptococcus(17 of18)
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Group A Streptococcus (GAS) causes many illnesses, including pharyngitis (strep throat), streptococcal toxic shock syndrome, necrotizing fasciitis (“flesh-eating” disease), scarlet fever, rheumatic fever, and skin infections such as impetigo. (credit:CDC)
Clindamycin-resistant Group B Streptococcus(18 of18)
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Group B Streptococcus (GBS) is a type of bacteria that can cause severe illnesses in people of all ages, ranging from bloodstream infections (sepsis) and pneumonia to meningitis and skin infections. (credit:CDC)
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