Ellen Pompeo Talks Emmy Quote Controversy, Opens Up About 'Grey's Anatomy' Cast On 'WWHL' (VIDEO)

It may have been Ellen Pompeo's first time in the "Watch What Happens: Live" clubhouse, but the "Grey's Anatomy" star was every bit as candid as the best of Andy Cohen's guests. It seemed that there were no questions he could pose that she wasn't willing to answer honestly.

When asked who was a better kisser out of Patrick Dempsey and Chris O'Donnell, she quickly answered Dempsey. As for why? "We don’t have that much time," Pompeo said.

Of T.R. Knight, Katherine Heigl and Isaiah Washington, Pompeo said she missed Heigl and Knight the most -- it was a tie. "T.R. and Katie are kind of the same person," she said. "They’re a sandwich.” When asked who was the "bigger bitch" to work with out of Heigl and Washington, Pompeo said, "Isaiah all the way!"

Washington was famously let go from the show after using homophobic slurs against castmate Knight. And Heigl left very publicly after she insulted the show's quality. That drama recently came back to haunt the actress in a Hollywood Reporter piece about how difficult she is to work with.

A caller wanted to know if Pompeo thought Heigl would ever return to "Grey's Anatomy," and Pompeo basically said, "No." She said that Heigl has a deal for a new CIA-themed series with NBC. The show is currently in development and Pompeo sent "much love" to her former co-star, saying that she can't wait to see it.

As for her show, Pompeo ranked the "Grey's Anatomy" musical episode below the one where Izzie had sex with Denny's ghost, though many fans believe they were equally awful, with still others having a soft spot for the weirdness that was that musical episode.

Pompeo also addressed some controversy over comments she made about the Emmys. She was quoted as calling the show "disappointing," noting that it "lacked diversity." But she told Cohen that her comments were made "off the record" -- as in while she was walking from the elevator into an interview. Her team is looking into what happened, but she stands by her quotes nonetheless.

The 10th season of "Grey's Anatomy" kicks off on Thursday at 9 p.m. ET on ABC. "Watch What Happens: Live" airs every Sunday through Thursday at 11 p.m. ET on Bravo.

TV Replay scours the vast television landscape to find the most interesting, amusing, and, on a good day, amazing moments, and delivers them right to your browser.