Everything You Should Know About Picking The Right Over-The-Counter Painkiller

Everything You Should Know About Picking The Right Over-The-Counter Painkiller
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Just about anyone who has ever had a headache or some knee pain has probably wondered: "How can I make this go away?"

Over-the-counter pain relievers are a pretty popular choice. In any given week, about 20 percent of the American population will use an OTC painkiller, according to a report from the American College of Preventive Medicine. And when asked to reflect over the last year, 87 percent of women and 80 percent of men say they have used such a medication.

OTC pain meds fall into two major categories: non-steroidal anti-inflammatory drugs (or NSAIDs) and acetaminophen. Both are non-opioid analgesics, meaning they reduce pain but aren't part of the family of drugs known as opioids. Opioids, powerful substances such as morphine, oxycodone and codeine, are classified as narcotics and require a prescription.

While we feel pain local to an injury or site of a particular ache, it's important to remember that pain is essentially an electrical signal sent to the brain. Acetaminophen seems to lessen the intensity of pain signals in the areas of the brain that process them. But in addition to these electrical messages, our bodies also create physical symptoms. Inflammation -- pain, swelling, redness -- is caused by prostaglandins, a ground of hormone-like substances, which NSAIDs can help control.

Both have their risks: Taking too much acetaminophen has been linked to liver problems, while taking too much of an NSAID has been linked to stomach problems and ulcers.

Different types of pain respond better to different types of painkillers, and because both are highly individual, what works best for someone else may not work best for you. As a general rule, you should not take a pain reliever if you already take any other products containing pain-relieving ingredients without consulting a medical professional. Do not take a pain reliever that contains any ingredients you know you are allergic to. And of course, discuss your personal medical history with a doctor before taking any over-the-counter medicine, especially if you take any other medications.

But to give you a better sense of what's behind the various boxes and bottles on your drugstore shelf, here are some of the basic differences (and, frankly, similarities) between some of the most popular OTC pain meds on the market.


Photo: advilaide.com
Do not use Advil if you have a stomach ulcer, are in the last three months of pregnancy or have three or more alcoholic drinks a day while using it. Talk to your doctor before use if you have kidney disease, liver cirrhosis or heartburn or are pregnant or breast-feeding.


Photo: alevepro.com
Do not use Aleve if you are in the last three months of pregnancy, have three or more alcoholic drinks a day while using it or have a stomach ulcer. Talk to your doctor before use if you are pregnant or breast-feeding or if you have high blood pressure.


Photo: aspirin.com
Do not take aspirin if you are in the last three months of pregnancy. Talk to your doctor before use if you are pregnant or taking a blood-thinning medication or medication for diabetes, gout or arthritis.


Photo: Facebook: Excedrin
Do not use Excedrin if you have or are recovering from the chicken pox or flu-like symptoms, are in the last three months of pregnancy or have three or more alcoholic drinks a day while using it. Talk to your doctor before use if you have a stomach ulcer, liver disease, heartburn, high blood pressure, liver cirrhoses, heart disease, kidney disease or asthma. Talk to your doctor if you have the worst headache of your life or a headache different from your usual headaches or you are vomiting with a migraine.


Photo: Midol.com
Do not take Midol if you have three or more alcoholic drinks a day while using it. Talk to your doctor before use if you have liver disease, glaucoma, a chronic breathing problem, are taking sedatives or are pregnant.


Photo: Motrin.com
Do not use Motrin if you have a stomach ulcer, are in the last three months of pregnancy or have three or more alcoholic drinks a day while using it. Talk to your doctor before use if you have kidney disease, liver cirrhosis or heartburn or are pregnant or breast-feeding.


Photo: Facebook: Tylenol
Do not use Tylenol if you have three or more alcoholic drinks a day while using it. Talk to your doctor before use if you have liver disease, take a blood-thinning drug or are pregnant.

Before You Go

Foods That Interact With Medicine
Kale And Blood Thinners(01 of05)
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Dark leafy greens like kale (but also: broccoli, chard and red leaf lettuces) are full of fiber and important vitamins and nutrients, including vitamin K -- an important antioxidant that also helps fortify bones and support brain function. The problem? It’s also a coagulant, so it promotes blood clotting. If you’re on a blood thinner, a healthful bowl of kale salad could counteract the work your medicine is doing. (credit:FLICKR: STACY SPENSLEY)
Dairy And Antibiotics(02 of05)
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If you’re taking a course of quinolones-based antibiotics, beware of anything rich in calcium, which can interfere with the body’s ability to absorb the medication. Antibiotics made with quinolones include popular drugs like Ciprofloxacin and other treatments often used for common ailments like urinary tract infections, pneumonia and bronchitis. (credit:Alamy)
Stinky Cheese, Cured Meat And Antidepressants(03 of05)
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If you’re into the gourmet tasting platters at pretty much any wine bar, beware. Both cured meats (salami, prosciutto, et al) and moldy, stinky cheeses like parmesan and blue cheese contain an amino acid called tyramine that can interfere with MAOI-based antidepressants. That’s because tyramine, which also occurs naturally in the body and works to regulate blood sugar, can start to build up to dangerous levels within those who take MAOIs. That’s because MAOIs also inhibit an enzyme, monoamine oxidase, that helps to break down tyramine in the blood stream. The body will naturally calibrate tyramine levels, but consuming excess tyramine can lead to a dangerous spike in blood pressure. The Mayo Clinic has a full list of foods high in tyramine. (credit:Getty Images)
Caffeine And, Well, A Lot Of Things(04 of05)
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Caffeine can interact with a wide range of medications. What’s more, some medications interfere with the body’s response to caffeine. Quinolones antibiotics, for example, can impede the body’s breakdown of caffeine, leading to extreme caffeine side effects like jitteriness and rapid heart beat. Estrogen, asthma medications and anti-anxiety medications can also have this effect. What’s more, caffeine hinders blood clotting, so those who take anticoagulants may find their blood so thinned that they experience bleeding. (credit: FLICKR: SORARIUM)
Licorice And Heart Medicine(05 of05)
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The FDA recommends avoiding licorice if you’re on digoxin, a drug for heart failure or abnormal heart rhythm because the herb-based candy can increase the risk of digoxin’s toxic effects. Those taking angiotensin converting enzyme (ACE) inhibitors for high blood pressure should also watch out for licorice, which can diminish their effectiveness and even lead to a build-up of potassium. (credit:shutterstock)

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